Research links childhood hypertension with cognitive issues



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We tend to associate hypertension with adults — the consequences of either genetic predisposition or bad diets and not enough physical activity. But high blood pressure has increased significantly in children, a disturbing parallel with the current childhood obesity epidemic.

Since this is a relatively new trend, little research has been done on the cognitive effects of childhood hypertension until now. In a new study scheduled for publication in The Journal of Pediatrics, researchers found that hypertension is indeed associated with cognitive issues in children and adolescents.

Marc B. Lande, MD, MPH, as well as researchers from the University of Rochester, Emory University, Maimonides Medical Center, University of Texas at Houston, University of North Carolina, Thomas Jefferson University, University of Maryland and the University of California at Los Angeles, compared different tests of cognitive skills between 75 10-18-year-old children with newly diagnosed hypertension and 75 matched children without hypertension. Children who had other factors that are known to affect cognitive skills were excluded from the study (e.g., ADHD, learning disabilities and sleep disorders).

“We wanted to make sure that if we found differences between children with and without hypertension, it was likely associated with the hypertension itself, not any of these other factors,” said Dr. Lande.

The researchers found the children with hypertension performed worse on the cognitive tests that measured visual and verbal memory, processing speed and verbal skills. Additionally, more children with sleep issues had hypertension, which intensified the effect of poor sleep on cognition and executive function. It is important to note that the differences between groups were small and that the average cognitive test scores of both groups were largely within normal ranges. The children with hypertension were not cognitively impaired, but simply didn’t perform as well as children without hypertension.

Overall, this study provides evidence that hypertension in children is associated with a subtle pattern of decreased performance on cognitive testing. “In the future, we want to better understand if there are physical changes to the brain in children who have hypertension that could explain these cognitive test results,” added Dr. Lande.

Knowing how these physical changes might affect cognitive skills could be important in future studies that assess whether antihypertensive treatments could improve cognitive performance in children with hypertension and reverse or prevent future adult hypertension-related problems.